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Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene

The Ncf1 gene was recently identified as a strong regulator of severe arthritis in rat. This finding was surprising, because the disease-promoting allele mediated a lower level of reactive oxygen species in NADPH oxidase-expressing cells. We have now investigated a splice mutation of the Ncf1 gene i...

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Autori principali: Hultqvist, Malin, Olofsson, Peter, Holmberg, Jens, Bäckström, B. Thomas, Tordsson, Jesper, Holmdahl, Rikard
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC515111/
https://ncbi.nlm.nih.gov/pubmed/15310853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403831101
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