Discovery of Novel Bruton’s Tyrosine Kinase (BTK) Inhibitors Bearing a N,9-Diphenyl-9H-purin-2-amine Scaffold

[Image: see text] Based on the pyrimidine skeleton of EGFR(T790M) inhibitors, a series of N,9-diphenyl-9H-purin-2-amine derivatives were identified as effective BTK inhibitors. Among these compounds, inhibitors 10d, 10i, and 10j, possessing IC(50) values of 0.5, 0.5, and 0.4 nM, displayed anti-BTK k...

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Publicado no:ACS Med Chem Lett
Main Authors: Ge, Yang, Jin, Yue, Wang, Changyuan, Zhang, Jianbin, Tang, Zeyao, Peng, Jinyong, Liu, Kexin, Li, Yanxia, Zhou, Youwen, Ma, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150693/
https://ncbi.nlm.nih.gov/pubmed/27994736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00235
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