Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ

[Image: see text] The aberrant activation of B-cells has been implicated in several types of cancers and hematological disorders. BTK and PI3Kδ are kinases responsible for B-cell signal transduction, and inhibitors of these enzymes have demonstrated clinical benefit in certain types of lymphoma. Sim...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Pujala, Brahmam, Agarwal, Anil K., Middya, Sandip, Banerjee, Monali, Surya, Arjun, Nayak, Anjan K., Gupta, Ashu, Khare, Sweta, Guguloth, Rambabu, Randive, Nitin A., Shinde, Bharat U., Thakur, Anamika, Patel, Dhananjay I., Raja, Mohd., Green, Michael J., Alfaro, Jennifer, Avila, Patricio, Pérez de Arce, Felipe, Almirez, Ramona G., Kanno, Stacy, Bernales, Sebastián, Hung, David T., Chakravarty, Sarvajit, McCullagh, Emma, Quinn, Kevin P., Rai, Roopa, Pham, Son M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150666/
https://ncbi.nlm.nih.gov/pubmed/27994757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00356
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