Nuclear Receptors CAR and PXR Cross Talk with FOXO1 To Regulate Genes That Encode Drug-Metabolizing and Gluconeogenic Enzymes

The nuclear receptors CAR and PXR activate hepatic genes in response to therapeutic drugs and xenobiotics, leading to the induction of drug-metabolizing enzymes, such as cytochrome P450. Insulin inhibits the ability of FOXO1 to express genes encoding gluconeogenic enzymes. Induction by drugs is know...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kodama, Susumu, Koike, Chika, Negishi, Masahiko, Yamamoto, Yukio
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2004
Gaiak:
Transcriptional Regulation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC515037/
https://ncbi.nlm.nih.gov/pubmed/15340055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.18.7931-7940.2004
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