Integrin-Linked Kinase Regulates Endothelial Cell Survival and Vascular Development

Integrin-linked kinase (ILK) is a phosphoinositide 3-kinase-dependent serine/threonine kinase that interacts with β integrins. Here we show that endothelial cell (EC)-specific deletion of ILK in mice confers placental insufficiency with decreased labyrinthine vascularization, yielding no viable offs...

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Bibliographische Detailangaben
Hauptverfasser: Friedrich, Erik B., Liu, Emerson, Sinha, Sumita, Cook, Stuart, Milstone, David S., MacRae, Calum A., Mariotti, Massimo, Kuhlencordt, Peter J., Force, Thomas, Rosenzweig, Anthony, St-Arnaud, Rene, Dedhar, Shoukat, Gerszten, Robert E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC515035/
https://ncbi.nlm.nih.gov/pubmed/15340074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.18.8134-8144.2004
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