Helper-Dependent Adenoviral Vector-Mediated Delivery of Woodchuck-Specific Genes for Alpha Interferon (IFN-α) and IFN-γ: IFN-α but Not IFN-γ Reduces Woodchuck Hepatitis Virus Replication in Chronic Infection In Vivo

Alpha interferon (IFN-α) and IFN-γ are able to suppress hepadnavirus replication. The intrahepatic expression of high levels of IFN may enhance the antiviral activity. We investigated the effects of woodchuck-specific IFN-α (wIFN-α) and IFN-γ(wIFN-γ) on woodchuck hepatitis virus (WHV) replication in...

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Bibliographische Detailangaben
Hauptverfasser: Fiedler, Melanie, Rödicker, Florian, Salucci, Valentina, Lu, Mengji, Aurisicchio, Luigi, Dahmen, Uta, Jun, Li, Dirsch, Olaf, Pützer, Brigitte M., Palombo, Fabio, Roggendorf, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC515010/
https://ncbi.nlm.nih.gov/pubmed/15331744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.18.10111-10121.2004
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