Long-Term Persistence of Infection in Chimpanzees Inoculated with an Infectious Hepatitis C Virus Clone Is Associated with a Decrease in the Viral Amino Acid Substitution Rate and Low Levels of Heterogeneity

Two chimpanzees, 1535 and 1536, became persistently infected following inoculation with RNA transcripts from cDNA clones of hepatitis C virus (HCV). Analysis of the HCV genomes from both animals showed an accumulation of amino acid substitutions over time. The appearance of substitutions in the enve...

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Detalhes bibliográficos
Main Authors: Fernandez, Javier, Taylor, Deborah, Morhardt, Duncan R., Mihalik, Kathleen, Puig, Montserrat, Rice, Charles M., Feinstone, Stephen M., Major, Marian E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC514970/
https://ncbi.nlm.nih.gov/pubmed/15331711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.18.9782-9789.2004
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