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Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF
The actin filament-severing functionality of gelsolin resides in its N-terminal three domains (G1–G3). We have determined the structure of this fragment in complex with an actin monomer. The structure reveals the dramatic domain rearrangements that activate G1–G3, which include the replacement of in...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514944/ https://ncbi.nlm.nih.gov/pubmed/15215896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600280 |
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