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Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis
Breakdown of triple-helical interstitial collagens is essential in embryonic development, organ morphogenesis and tissue remodelling and repair. Aberrant collagenolysis may result in diseases such as arthritis, cancer, atherosclerosis, aneurysm and fibrosis. In vertebrates, it is initiated by collag...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514933/ https://ncbi.nlm.nih.gov/pubmed/15257288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600318 |
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