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Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint
The spindle checkpoint inhibits anaphase until all kinetochores have attached properly to spindle microtubules. The protein kinase Bub1 is an essential checkpoint component that resides at kinetochores during mitosis. It is shown herein that Xenopus Bub1 becomes hyperphosphorylated and the kinase is...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514925/ https://ncbi.nlm.nih.gov/pubmed/15241477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600308 |
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