Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization

Stress granules are membrane-less organelles composed of RNA-binding proteins (RBPs) and RNA. Functional impairment of stress granules has been implicated in amyotrophic lateral sclerosis, frontotemporal dementia and multisystem proteinopathy - diseases that are characterized by fibrillar inclusions...

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Publicat a:Cell
Autors principals: Molliex, Amandine, Temirov, Jamshid, Lee, Jihun, Coughlin, Maura, Kanagaraj, Anderson P., Kim, Hong Joo, Mittag, Tanja, Taylor, J. Paul
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5149108/
https://ncbi.nlm.nih.gov/pubmed/26406374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.09.015
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