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Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization
Stress granules are membrane-less organelles composed of RNA-binding proteins (RBPs) and RNA. Functional impairment of stress granules has been implicated in amyotrophic lateral sclerosis, frontotemporal dementia and multisystem proteinopathy - diseases that are characterized by fibrillar inclusions...
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| Udgivet i: | Cell |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5149108/ https://ncbi.nlm.nih.gov/pubmed/26406374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.09.015 |
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