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ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models
BACKGROUND: Autophagy is a bulk degradation pathway for long-lived proteins, protein aggregates, and damaged organelles. ULK1 protein kinase and Vps34 lipid kinase are two key autophagy regulators that are critical for autophagosome biogenesis. However, it isn’t fully understood how ULK1 regulates V...
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| Publicado no: | Mol Neurodegener |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5148922/ https://ncbi.nlm.nih.gov/pubmed/27938392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0141-0 |
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