Genetic polymorphisms of enzyme proteins and transporters related to methotrexate response and pharmacokinetics in a Japanese population

BACKGROUND: Methotrexate (MTX) is currently the anchor drug widely used worldwide in the treatment of rheumatoid arthritis (RA). However, the therapeutic response to MTX has been shown to vary widely among individuals, genders and ethnic groups. The reason for this has been not clarified but it is c...

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書目詳細資料
發表在:J Pharm Health Care Sci
Main Authors: Hashiguchi, Masayuki, Shimizu, Mikiko, Hakamata, Jun, Tsuru, Tomomi, Tanaka, Takanori, Suzaki, Midori, Miyawaki, Kumika, Chiyoda, Takeshi, Takeuchi, Osamu, Hiratsuka, Jiro, Irie, Shin, Maruyama, Junya, Mochizuki, Mayumi
格式: Artigo
語言:Inglês
出版: BioMed Central 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148839/
https://ncbi.nlm.nih.gov/pubmed/27980801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40780-016-0069-0
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