Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice

Trehalose biosynthesis is considered an attractive target for the development of antimicrobials against fungal, helminthic and bacterial pathogens including Mycobacterium tuberculosis. The most common biosynthetic route involves trehalose-6-phosphate (T6P) synthase OtsA and T6P phosphatase OtsB that...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Korte, Jan, Alber, Marina, Trujillo, Carolina M., Syson, Karl, Koliwer-Brandl, Hendrik, Deenen, René, Köhrer, Karl, DeJesus, Michael A., Hartman, Travis, Jacobs, William R., Bornemann, Stephen, Ioerger, Thomas R., Ehrt, Sabine, Kalscheuer, Rainer
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148154/
https://ncbi.nlm.nih.gov/pubmed/27936238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006043
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