Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice

Trehalose biosynthesis is considered an attractive target for the development of antimicrobials against fungal, helminthic and bacterial pathogens including Mycobacterium tuberculosis. The most common biosynthetic route involves trehalose-6-phosphate (T6P) synthase OtsA and T6P phosphatase OtsB that...

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Gepubliceerd in:PLoS Pathog
Hoofdauteurs: Korte, Jan, Alber, Marina, Trujillo, Carolina M., Syson, Karl, Koliwer-Brandl, Hendrik, Deenen, René, Köhrer, Karl, DeJesus, Michael A., Hartman, Travis, Jacobs, William R., Bornemann, Stephen, Ioerger, Thomas R., Ehrt, Sabine, Kalscheuer, Rainer
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148154/
https://ncbi.nlm.nih.gov/pubmed/27936238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006043
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