Safety, Pharmacokinetics, Pharmacodynamics, and Plasma Lipoprotein Distribution of Eritoran (E5564) during Continuous Intravenous Infusion into Healthy Volunteers

Eritoran, a structural analogue of the lipid A portion of lipopolysaccharide (LPS), is an antagonist of LPS in animal and human endotoxemia models. Previous studies have shown that low doses (350 to 3,500 μg) of eritoran have demonstrated a long pharmacokinetic half-life but a short pharmacodynamic...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Rossignol, Daniel P., Wasan, Kishor M., Choo, Eugene, Yau, Edwin, Wong, Nancy, Rose, Jeffrey, Moran, Jeffrey, Lynn, Melvyn
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2004
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514793/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15328078/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.9.3233-3240.2004
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