Safety, Pharmacokinetics, Pharmacodynamics, and Plasma Lipoprotein Distribution of Eritoran (E5564) during Continuous Intravenous Infusion into Healthy Volunteers

Eritoran, a structural analogue of the lipid A portion of lipopolysaccharide (LPS), is an antagonist of LPS in animal and human endotoxemia models. Previous studies have shown that low doses (350 to 3,500 μg) of eritoran have demonstrated a long pharmacokinetic half-life but a short pharmacodynamic...

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Bibliographic Details
Main Authors: Rossignol, Daniel P., Wasan, Kishor M., Choo, Eugene, Yau, Edwin, Wong, Nancy, Rose, Jeffrey, Moran, Jeffrey, Lynn, Melvyn
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC514793/
https://ncbi.nlm.nih.gov/pubmed/15328078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.9.3233-3240.2004
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