Inflammation induced oxidative stress mediates gene fusion formation in prostate cancer

Approximately 50% of prostate cancers are associated with gene fusions of the androgen-regulated gene, TMPRSS2, to the oncogenic ETS transcription factor, ERG. The three-dimensional proximity of TMPRSS2 and ERG genes, in combination with DNA breaks facilitate the formation of TMPRSS2-ERG gene fusion...

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Publicado no:Cell Rep
Main Authors: Mani, Ram S., Amin, Mohammad A., Li, Xiangyi, Kalyana-Sundaram, Shanker, Veeneman, Brendan A., Wang, Lei, Ghosh, Aparna, Aslam, Adam, Ramanand, Susmita G., Rabquer, Bradley J., Kimura, Wataru, Tran, Maxwell, Cao, Xuhong, Roychowdhury, Sameek, Dhanasekaran, Saravana M., Palanisamy, Nallasivam, Sadek, Hesham A., Kapur, Payal, Koch, Alisa E., Chinnaiyan, Arul M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147555/
https://ncbi.nlm.nih.gov/pubmed/27926866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.019
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