Identification of GPR83 as the receptor for the neuroendocrine peptide PEN

PEN is an abundant peptide in the brain that has been implicated in the regulation of feeding. We identified a receptor for PEN in mouse hypothalamus and Neuro2A cells. PEN bound to and activated GPR83, a G protein (heterotrimeric guanine nucleotide–binding protein)–coupled receptor (GPCR). Reductio...

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Publicado en:Sci Signal
Main Authors: Gomes, Ivone, Bobeck, Erin N., Margolis, Elyssa B., Gupta, Achla, Sierra, Salvador, Fakira, Amanda K., Fujita, Wakako, Müller, Timo D., Müller, Anne, Tschöp, Matthias H., Kleinau, Gunnar, Fricker, Lloyd D., Devi, Lakshmi A.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147544/
https://ncbi.nlm.nih.gov/pubmed/27117253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad0694
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