CD69 controls L-Trp uptake through LAT1-CD98 and AhR-dependent IL-22 secretion in psoriasis

The activation marker CD69 is expressed by skin γδ T cells. Here we demonstrate that CD69 controlled the aryl hydrocarbon receptor (AhR)-dependent interleukin 22 (IL-22) secretion in γδ T cells, which contributed to psoriasis development induced by IL-23. CD69 associated with the aromatic amino acid...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Cibrián Vera, Danay, Saiz, María Laura, de la Fuente, Hortensia, Sánchez-Díaz, Raquel, Moreno-Gonzalo, Olga, Jorge Cerrudo, Inmaculada, Ferrarini, Alessia, Vázquez, Jesús, Punzón, Carmen, Fresno, Manuel, Vicente-Manzanares, Miguel, Daudén Tello, Esteban, Fernández-Salguero, Pedro M., Martín, Pilar, Sánchez-Madrid, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5146640/
https://ncbi.nlm.nih.gov/pubmed/27376471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3504
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