Rational design of receptor-specific variants of human growth hormone.
Human growth hormone (hGH) binds to both the growth hormone (GH) and the prolactin (PRL) receptors. Competition experiments followed by mutational analysis show that the epitope on hGH for hPRL receptor consists of strong determinants in the middle of helix 1 (comprising residues His-18, His-21, and...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1991
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51456/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2014261/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.8.3407 |
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