The Ebola Interferon Inhibiting Domains Attenuate and Dysregulate Cell-Mediated Immune Responses

Ebola virus (EBOV) infections are characterized by deficient T-lymphocyte responses, T-lymphocyte apoptosis and lymphopenia. We previously showed that disabling of interferon-inhibiting domains (IIDs) in the VP24 and VP35 proteins effectively unblocks maturation of dendritic cells (DCs) and increase...

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Pubblicato in:PLoS Pathog
Autori principali: Lubaki, Ndongala Michel, Younan, Patrick, Santos, Rodrigo I., Meyer, Michelle, Iampietro, Mathieu, Koup, Richard A., Bukreyev, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145241/
https://ncbi.nlm.nih.gov/pubmed/27930745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006031
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