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Dodecylphosphocholine Micelles Induce Amyloid Formation of the PrP(110-136) Peptide via an α-Helical Metastable Conformation

A peptide encompassing the conserved hydrophobic region and the first β-strand of the prion protein (PrP(110–136)) shown to interact with the surface of dodecylphosphocholine micelles adopts an α-helical conformation that is localized below the head-group layer. This surface-bound peptide has a half...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sauvé, Simon, Aubin, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145231/
https://ncbi.nlm.nih.gov/pubmed/27930722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168021
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