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Vertical collapse of a cytolysin prepore moves its transmembrane β-hairpins to the membrane

Perfringolysin O (PFO) is a prototype of the large family of pore-forming cholesterol-dependent cytolysins (CDCs). A central enigma of the cytolytic mechanism of the CDCs is that their membrane-spanning β-hairpins (the transmembrane amphipathic β-hairpins (TMHs)) appear to be ∼40 Å too far above the...

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Autores principales: Czajkowsky, Daniel M, Hotze, Eileen M, Shao, Zhifeng, Tweten, Rodney K
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2004
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC514522/
https://ncbi.nlm.nih.gov/pubmed/15297878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600350
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