Combining Genome Wide Association Study and lung eQTL analysis provides evidence for novel genes associated with asthma

BACKGROUND: Genome wide association studies (GWAS) of asthma have identified single nucleotide polymorphisms (SNPs) that modestly increase the risk for asthma. This could be due to phenotypic heterogeneity of asthma. Bronchial hyperresponsiveness (BHR) is a phenotypic hallmark of asthma. We aim to i...

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Publicado en:Allergy
Main Authors: Nieuwenhuis, Maartje A., Siedlinski, Matteusz, van den Berge, Maarten, Granell, Raquel, Li, Xingnan, Niens, Marijke, van der Vlies, Pieter, Altmüller, Janine, Nürnberg, Peter, Kerkhof, Marjan, van Schayck, Onno C., Riemersma, Ronald A., van der Molen, Thys, de Monchy, Jan G., Bossé, Yohan, Sandford, Andrew, Bruijnzeel-Koomen, Carla A., van Wijk, Roy G., ten Hacken, Nick H., Timens, Wim, Boezen, H. Marike, Henderson, John, Kabesch, Michael, Vonk, Judith M., Postma, Dirkje S., Koppelman, Gerard H.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145001/
https://ncbi.nlm.nih.gov/pubmed/27439200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/all.12990
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