Metallothionein Prevents Age-Associated Cardiomyopathy via Inhibiting NF-κB Pathway Activation and Associated Nitrative Damage to 2-OGD

Aims: Cardiac-specific metallothionein (MT) overexpression extends lifespan, but the mechanism underlying the effect of MT protection against age-associated cardiovascular diseases (CVD) remains elusive. To elucidate this, male wild-type and two lines of MT-transgenic (MT-TG) mice, MM and MT-1 (card...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Cong, Weitao, Niu, Chao, Lv, Lingchun, Ni, Maowei, Ruan, Dandan, Chi, Lisha, Wang, Yang, Yu, Qing, Zhan, Kungao, Xuan, Yuanhu, Wang, Yuehui, Tan, Yi, Wei, Tiemin, Cai, Lu, Jin, Litai
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144888/
https://ncbi.nlm.nih.gov/pubmed/27477335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2016.6648
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