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Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation
The tumor suppressor gene p53 controls cellular response to a variety of stress conditions, including DNA damage and hypoxia, leading to growth arrest and/or apoptosis. Inactivation of p53, found in 40–50% of human cancers, confers selective advantage under hypoxic microenvironment during tumor prog...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514462/ https://ncbi.nlm.nih.gov/pubmed/15302922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404998101 |
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