Maternal and Fetal Mechanisms of B Cell Regulation during Pregnancy: Human Chorionic Gonadotropin Stimulates B Cells to Produce IL-10 While Alpha-Fetoprotein Drives Them into Apoptosis

Maternal immune tolerance toward the fetus is an essential requisite for pregnancy. While T cell functions are well documented, little is known about the participation of B cells. We have previously suggested that IL-10-producing B cells are involved in pregnancy tolerance in mice and humans. By emp...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Fettke, Franziska, Schumacher, Anne, Canellada, Andrea, Toledo, Natalia, Bekeredjian-Ding, Isabelle, Bondt, Albert, Wuhrer, Manfred, Costa, Serban-Dan, Zenclussen, Ana Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144100/
https://ncbi.nlm.nih.gov/pubmed/28008329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00495
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