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Intermolecular Interactions in the TMEM16A Dimer Controlling Channel Activity
TMEM16A and TMEM16B are plasma membrane proteins with Ca(2+)-dependent Cl(−) channel function. By replacing the carboxy-terminus of TMEM16A with the equivalent region of TMEM16B, we obtained channels with potentiation of channel activity. Progressive shortening of the chimeric region restricted the...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5144075/ https://ncbi.nlm.nih.gov/pubmed/27929144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38788 |
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