Generation of pokeweed antiviral protein mutations in Saccharomyces cerevisiae: evidence that ribosome depurination is not sufficient for cytotoxicity

Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein that depurinates the highly conserved α-sarcin/ricin loop in the large rRNA. Here, using site-directed mutagenesis and systematic deletion analysis from the 5′ and the 3′ ends of the PAP cDNA, we identified the amino acids important...

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Библиографические подробности
Главные авторы: Hudak, Katalin A., Parikh, Bijal A., Di, Rong, Baricevic, Marianne, Santana, Maria, Seskar, Mirjana, Tumer, Nilgun E.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2004
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC514378/
https://ncbi.nlm.nih.gov/pubmed/15304562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh757
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