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Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)

Cytosine methylation in CpG dinucleotides is believed to be important in gene regulation, and is generally associated with reduced levels of transcription. Methylation-mediated gene silencing involves a series of DNA–protein and protein–protein interactions that begins with the binding of methyl-CpG...

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Udgivet i:Nucleic Acids Res
Principais autores: Valinluck, Victoria, Tsai, Hsin-Hao, Rogstad, Daniel K., Burdzy, Artur, Bird, Adrian, Sowers, Lawrence C.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2004
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514367/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15302911/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh739
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