The Methyl-CpG-binding domain (MBD) is crucial for MeCP2’s dysfunction-induced defects in adult newborn neurons

Mutations in the human X-linked gene MECP2 are responsible for most Rett syndrome (RTT) cases, predominantly within its methyl-CpG-binding domain (MBD). To examine the role of MBD in the pathogenesis of RTT, we generated two MeCP2 mutant constructs, one with a deletion of MBD (MeCP2-ΔMBD), another...

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Bibliografiske detaljer

Principais autores:	Na eZhao, Dongliang eMa, Wan Ying eLeong, Ju eHan, Antonius eVanDongen, Teng eChen, Eyleen L Goh
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2015-04-01
Serier:	Frontiers in Cellular Neuroscience
Fag:	Dendrites newborn neurons Rett Syndrome (RTT) spontaneuos Ca2+ oscillation methyl-CpG binding protein 2 (MeCP2)
Online adgang:	http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00158/full
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