Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis

Fatty acid biosynthesis (FAS) is a vital process in cells. Fatty acids are essential for cell assembly and cellular metabolism. Abnormal FAS directly correlates with cell growth delay and human diseases, such as metabolic syndromes and various cancers. The FAS system utilizes an acyl carrier protein...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Zhang, Lin, Xiao, Jianfeng, Xu, Jianrong, Fu, Tianran, Cao, Zhiwei, Zhu, Liang, Chen, Hong-Zhuan, Shen, Xu, Jiang, Hualiang, Zhang, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143422/
https://ncbi.nlm.nih.gov/pubmed/27874013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.136
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