A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death

An important regulator of inflammatory signalling is the ubiquitin-editing protein A20 that acts as a break on nuclear factor-κB (NF-κB) activation, but also exerts important cytoprotective functions. A20 knockout mice are cachectic and die prematurely due to excessive multi-organ inflammation. To e...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Catrysse, L, Farhang Ghahremani, M, Vereecke, L, Youssef, S A, Mc Guire, C, Sze, M, Weber, A, Heikenwalder, M, de Bruin, A, Beyaert, R, van Loo, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143384/
https://ncbi.nlm.nih.gov/pubmed/27253414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.154
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