Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

A20 is a nuclear factor κB (NF-κB) target gene that encodes a ubiquitin-editing enzyme that is essential for the termination of NF-κB activation after tumor necrosis factor (TNF) or microbial product stimulation and for the prevention of TNF-induced apoptosis. Mice lacking A20 succumb to inflammatio...

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Autores principales: Vereecke, Lars, Sze, Mozes, Guire, Conor Mc, Rogiers, Brecht, Chu, Yuanyuan, Schmidt-Supprian, Marc, Pasparakis, Manolis, Beyaert, Rudi, van Loo, Geert
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901067/
https://ncbi.nlm.nih.gov/pubmed/20530205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092474
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