Rapid hepatic clearance of full length CCN-2/CTGF: a putative role for LRP1-mediated endocytosis

CCN-2 (connective tissue growth factor; CTGF) is a key factor in fibrosis. Plasma CCN-2 has biomarker potential in numerous fibrotic disorders, but it is unknown which pathophysiological factors determine plasma CCN-2 levels. The proteolytic amino-terminal fragment of CCN-2 is primarily eliminated b...

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Detalhes bibliográficos
Publicado no:J Cell Commun Signal
Main Authors: Gerritsen, K. G. F., Bovenschen, N., Nguyen, T. Q., Sprengers, D., Koeners, M. P., van Koppen, A. N., Joles, J. A., Goldschmeding, R., Kok, R. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143326/
https://ncbi.nlm.nih.gov/pubmed/27644406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-016-0354-6
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