AB283. SPR-10 Down-regulation of ryanodine receptor gene expression in murine urinary bladder smooth muscle following partial bladder outlet obstruction

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• Amino acid mutations in the caldesmon COOH-terminal functional domain increase force generation in bladder smooth muscle
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• Mechanical stretch upregulates proteins involved in Ca(2+) sensitization in urinary bladder smooth muscle hypertrophy
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• Smooth Muscle Hypertrophy Following Partial Bladder Outlet Obstruction Is Associated with Overexpression of Non-Muscle Caldesmon
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• NF-κB and GATA-Binding Factor 6 Repress Transcription of Caveolins in Bladder Smooth Muscle Hypertrophy
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• Transcriptional Repression of Caveolin-1 (CAV1) Gene Expression by GATA-6 in Bladder Smooth Muscle Hypertrophy in Mice and Human Beings
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