Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats

The current study examined the effect of obesity on the development of renal injury within the genetic background of the Dahl salt-sensitive rat with a dysfunctional leptin receptor derived from zinc-finger nucleases (SS(LepR)mutant strain). At 6 wk of age, body weight was 35% higher in the SS(LepR)...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: McPherson, Kasi C., Taylor, Lateia, Johnson, Ashley C., Didion, Sean P., Geurts, Aron M., Garrett, Michael R., Williams, Jan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Translational Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142236/
https://ncbi.nlm.nih.gov/pubmed/27465994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00590.2015
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