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An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue
The c-Jun NH(2)-terminal kinase (JNK) is activated during obesity. One consequence of obesity is that JNK phosphorylates the adapter protein insulin receptor substrate 1 (IRS-1) on Ser 307 and inhibits signaling by the insulin receptor. JNK can therefore cause peripheral insulin resistance during ob...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514178/ https://ncbi.nlm.nih.gov/pubmed/15314024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1216504 |
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