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The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops.

The E2 transactivator protein of bovine papillomavirus binds its specific DNA target sequence as a dimer. We have found that E2 dimers, preformed in solution independent of DNA, exhibit substantial cooperativity of DNA binding as detected by both nitrocellulose filter retention and footprint analysi...

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Bibliografski detalji
Glavni autori: Knight, J D, Li, R, Botchan, M
Format: Artigo
Jezik:Inglês
Izdano: 1991
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC51414/
https://ncbi.nlm.nih.gov/pubmed/1849647
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