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Designs for Phase I trials in ordered groups

We propose a new design for dose finding for cytotoxic agents in two ordered groups of patients. By ordered groups, we mean that prior to the study, there is clinical information that would indicate that for a given dose, one group would be more susceptible to toxicities than patients in the other g...

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Publicado en:Stat Med
Autores principales: Conaway, Mark R., Wages, Nolan A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5140690/
https://ncbi.nlm.nih.gov/pubmed/27624880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.7133
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