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Designs for Phase I trials in ordered groups
We propose a new design for dose finding for cytotoxic agents in two ordered groups of patients. By ordered groups, we mean that prior to the study, there is clinical information that would indicate that for a given dose, one group would be more susceptible to toxicities than patients in the other g...
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| Publié dans: | Stat Med |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5140690/ https://ncbi.nlm.nih.gov/pubmed/27624880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.7133 |
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