Characterization of a monoclonal antibody as the first specific inhibitor of human NTP diphosphohydrolase-3: Partial characterization of the inhibitory epitope and potential applications

The study and therapeutic modulation of purinergic signaling is hindered by a lack of specific inhibitors for NTP diphosphohydrolases (NTPDases), which are the terminating enzymes for these processes. In addition, little is known of the NTPDase protein structural elements that affect enzymatic activ...

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Bibliographic Details
Published in:FEBS J
Main Authors: Munkonda, Mercedes N., Pelletier, Julie, Ivanenkov, Vasily V., Fausther, Michel, Tremblay, Alain, Künzli, Beat, Kirley, Terence L., Sévigny, Jean
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5140288/
https://ncbi.nlm.nih.gov/pubmed/19120451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2008.06797.x
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