Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers

BACKGROUND: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy. Spatial relationships among cells including cancer and stromal cells in the tumor microenvironment (TME) are key contributors to he...

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Detalhes bibliográficos
Publicado no:J Pathol Inform
Main Authors: Spagnolo, Daniel M., Gyanchandani, Rekha, Al-Kofahi, Yousef, Stern, Andrew M., Lezon, Timothy R., Gough, Albert, Meyer, Dan E., Ginty, Fiona, Sarachan, Brion, Fine, Jeffrey, Lee, Adrian V., Taylor, D. Lansing, Chennubhotla, S. Chakra
Formato: Artigo
Idioma:Inglês
Publicado em: Medknow Publications & Media Pvt Ltd 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5139455/
https://ncbi.nlm.nih.gov/pubmed/27994939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/2153-3539.194839
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