Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers

BACKGROUND: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy. Spatial relationships among cells including cancer and stromal cells in the tumor microenvironment (TME) are key contributors to he...

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Détails bibliographiques
Publié dans:J Pathol Inform
Auteurs principaux: Spagnolo, Daniel M., Gyanchandani, Rekha, Al-Kofahi, Yousef, Stern, Andrew M., Lezon, Timothy R., Gough, Albert, Meyer, Dan E., Ginty, Fiona, Sarachan, Brion, Fine, Jeffrey, Lee, Adrian V., Taylor, D. Lansing, Chennubhotla, S. Chakra
Format: Artigo
Langue:Inglês
Publié: Medknow Publications & Media Pvt Ltd 2016
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5139455/
https://ncbi.nlm.nih.gov/pubmed/27994939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/2153-3539.194839
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