Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection

SAMHD1 restricts human immunodeficiency virus type 1 (HIV-1) replication in myeloid cells and CD4(+) T cells, while Vpx can mediate SAMHD1 degradation to promote HIV-1 replication. Although the restriction mechanisms of SAMHD1 have been well-described, SAMHD1 expression and Vpx-mediated SAMHD1 degra...

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Publicado no:Sci Rep
Main Authors: Fu, Weihui, Qiu, Chao, Zhou, Mingzhe, Zhu, Lingyan, Yang, Yu, Qiu, Chenli, Zhang, Linxia, Xu, Xuan, Wang, Ying, Xu, Jianqing, Zhang, Xiaoyan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5138643/
https://ncbi.nlm.nih.gov/pubmed/27922067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38162
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