pH-Responsive Triblock Copolymeric Micelles Decorated with a Cell-Penetrating Peptide Provide Efficient Doxorubicin Delivery

ABSTRACT: This study developed novel triblock pH-responsive polymeric micelles (PMs) using cholic acid-polyethyleneimine-poly-l-arginine (CA-PEI-pArg) copolymers. PEI provided pH sensitivity, while the hydrophilic cell-penetrating pArg peptide promoted cellular PM internalization. The copolymers sel...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nanoscale Res Lett
Auteurs principaux: Ng, Khen Eng, Amin, Mohd Cairul Iqbal Mohd, Katas, Haliza, Amjad, Muhammad Wahab, Butt, Adeel Masood, Kesharwani, Prashant, Iyer, Arun K.
Format: Artigo
Langue:Inglês
Publié: Springer US 2016
Sujets:
Nano Express
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5138181/
https://ncbi.nlm.nih.gov/pubmed/27921280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s11671-016-1755-4
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