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Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration

Skeletal muscle regenerative potential declines with age, in part due to deficiencies in resident stem cells (satellite cells, SCs) and derived myogenic progenitors (MPs); however, the factors responsible for this decline remain obscure. TGFβ superfamily signaling is an inhibitor of myogenic differe...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Paris, Nicole D, Soroka, Andrew, Klose, Alanna, Liu, Wenxuan, Chakkalakal, Joe V
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5138033/
https://ncbi.nlm.nih.gov/pubmed/27855784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19484
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