New hits as phase II enzymes inducers from a focused library with heteroatom–heteroatom and Michael-acceptor motives

The increased activity of phase-II-detoxification enzymes, such as quinone reductase (QR) and glutation S-transferase (GST), correlates with protection against chemically induced carcinogenesis. Herein we studied 11 different chemotypes, pyrazole, 1,2,4-oxadiazole, 1,2,5-oxadiazole, 1,2,3-thiadiazol...

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Dades bibliogràfiques
Publicat a:Future Sci OA
Autors principals: Cabrera, Mauricio, de Ovalle, Stefani, Bollati-Fogolín, Mariela, Nascimento, Fabiana, Corbelini, Patrícia, Janarelli, Fernanda, Kawano, Daniel, Eifler-Lima, Vera Lucia, González, Mercedes, Cerecetto, Hugo
Format: Artigo
Idioma:Inglês
Publicat: Future Science Ltd 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137958/
https://ncbi.nlm.nih.gov/pubmed/28031894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fso.15.18
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