Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors

Programmed cell death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) checkpoint blockade has led to remarkable and durable objective responses in a number of different tumor types. A better understanding of factors associated with the PD-1/PD-L axis expression is desirable, as it informs their p...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Danilova, Ludmila, Wang, Hao, Sunshine, Joel, Kaunitz, Genevieve J., Cottrell, Tricia R., Xu, Haiying, Esandrio, Jessica, Anders, Robert A., Cope, Leslie, Pardoll, Drew M., Drake, Charles G., Taube, Janis M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137776/
https://ncbi.nlm.nih.gov/pubmed/27837027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607836113
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