Casposon integration shows strong target site preference and recapitulates protospacer integration by CRISPR-Cas systems

Casposons are a recently discovered group of large DNA transposons present in diverse bacterial and archaeal genomes. For integration into the host chromosome, casposons employ an endonuclease that is homologous to the Cas1 protein involved in protospacer integration by the CRISPR-Cas adaptive immun...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Béguin, Pierre, Charpin, Nicole, Koonin, Eugene V., Forterre, Patrick, Krupovic, Mart
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Nucleic Acid Enzymes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137440/
https://ncbi.nlm.nih.gov/pubmed/27655632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw821
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